Pro-inflammatory cytokine is a type of signaling molecule that is secreted from immune cells like helper T cells and macrophages, and other cell types that promote inflammation like interleukin 1(IL-1), (IL-12) (IL-18), TNF-α, interferon gamma, granulocytes, macrophages and colony stimulating factor (GM-GSF). They play important role in mediation in initiate immune response. Inflammatory cytokines are predominantly produced and are involved in up regulation of inflammatory reaction. Most frequently Inflammatory diseases in dental medicine are periodontal diseases. Many studies have indicate that biological activity of variety of cytokines may be directly relevant to periodontal destruction. Draw of the initiation is well documented and the end result is destruction of alveolar bone and periodontal connective tissue. This is readily observe but the events between this two points in time remain obscure and are the focus of this paper. Bacteria from plaque formation induces tissue destruction indirectly by activating host defense cells, and tissue breakdown components of dental plaque have the capacity to induce the initial infiltrate of inflammatory cells including lymphocytes macrophages, PMNs. Bacteria can cause damage directly and indirectly. Cytotoxic cellular immune responses to self and pro-inflammatory responses are involved in releases of many cytokines and chemokines.
SREDOVSKA, A.,
&
NAKOVA, M.,
(2021). REVIEW OF INFLAMMATORY CYTOKINES IN DENTISTRY. International Journal of Technical and Natural Sciences, 2(2), 70-75. Arrival Date Posted By:https://ijtns.ibupress.com/articles/review-of-inflammatory-cytokines-in-dentistry
