Research Article

GLUCOCORTICOIDS IN ORAL MEDICINE

ABSTRACT

Through, widely known as the body’s stress hormone, cortisol has a variety of effects on the different functions of the body; it is mainly been released from the zonа fasciculata, a layer of the adrenal cortex. Glucocorticosteroid receptors are present in almost all tissue in the body. Therefore, cortisol is able to affect nearly every organ and system: nervous, immune, cardiovascular, respiratory, reproductive, musculoskeletal, and oral disorders. Cortisol has many functions in the human body, such as mediating the stress response, regulating metabolism, inflammatory responses, and immune function. Steroids are been used as anti-inflammatory, antiallergic, and immunosuppressive drugs in many general and oral diseases. Steroids can be manufactured synthetically as drugs, available in the form of fluid for injections, tablets, ointment, solution, and gels. Steroids are of the most broadly used drugs in dentistry and readily act as an immunosuppressive agent. Corticosteroids have modernized the treatment protocol for several disease conditions inclusive of many oral diseases. These are strong and effective anti-inflammatory drugs resembling cortisol. Their function is to decrease inflammation, particularly when the body inaccurately activates the inflammatory system. Many oral and maxillofacial clinicians apply the usage of corticosteroids established on their effectiveness to control the consequences of any dental procedure or surgery. The present review focused on the pharmacology, use of corticosteroids in oral medicine, and side effects of corticosteroids.

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