The Role of Pancreatic Stone Protein as a Predictor of Sepsis in the Intensive Care Unit and Its Correlation With D-Dimer, C-Reactive Protein, and Procalcitonin the-role-of-pancreatic-stone-protein-as-a-predictor-of-sepsis-in-the-intensive-care-unit-and-its-correlation-with-d-dimer-c-reactive-protein-and-procalcitonin Volume 5, Issue 2 ARTICLES 2025 5 Pancreatic stone protein (PSP) is secreted by pancreatic acinar cells. PSP is a damage-associated molecular pattern (DAMP) produced in response to sepsis. The study aims to determine the association between PSP values and sepsis criteria, SOFA score, mortality, and values of D-dimer, WBC, CRP, and Procalcitonin on admission to the ICU. This is a monocentric retrospective study that includes 63 patients, with a mean age of 62.5±15.5 years, with PSP values measured on admission to the ICU. Patients were stratified as having normal PSP values, low, moderate, or high risk for sepsis and compared with the classification based on the Third International Consensus Definitions for Sepsis and Septic Shock and to their SOFA score and laboratory parameters, including WBC, CRP, D-dimer, and Procalcitonin. A statistically significant difference was confirmed in the distribution of patients with normal PSP values, with low, moderate and high risk for sepsis according to PSP values in terms of not meeting sepsis criteria (p=0.0000), meeting SIRS criteria (p=0.029), meeting sepsis criteria (p=0.022) and meeting septic shock criteria (p=0.000), while, the difference in terms of severe sepsis criteria was not statistically significant (p=0.88). PSP significantly positively correlated with D-dimers, CRP, and PCT (R =0.4462, p=0.0008; R =0.4971, p=0.00003; and R=0.5825, p=0.000001, respectively). PSP may play a role as a predictor of sepsis severity and mortality in patients in the ICU.

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]]> PSP, sepsis, SOFA, Intensive Care Unit https://ijtns.ibupress.com/articles/the-role-of-pancreatic-stone-protein-as-a-predictor-of-sepsis-in-the-intensive-care-unit-and-its-correlation-with-d-dimer-c-reactive-protein-and-procalcitonin